Methods: High-throughput sequencing was performed on colorectal cancer (CRC) cells before and after glutaminolysis inhibition to identify differentially expressed genes. Hence, we investigated the mechanism underlying glutaminolysis inhibition-induced pro-survival autophagy. However, glutaminolysis inhibition leads to activation of autophagy, which compromises its antitumor effect. File import instruction AbstractĪs glutamine plays a central role in cancer metabolism, inhibition of glutaminolysis has become an ideal anticancer therapeutic target. Select the file that you have just downloaded and select import option Reference Manager (RIS). Available fromĬlick on Go to download the file. Targeting ATF4-dependent pro-survival autophagy to synergize glutaminolysis inhibition. Han S, Zhu L, Zhu Y, Meng Y, Li J, Song P, Yousafzai NA, Feng L, Chen M, Wang Y, Jin H, Wang X.
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